For example, many proteins are modified shortly after translation is completed to mediate proper protein folding or stability or to direct the nascent protein to distinct cellular compartments (e.g., nucleus, membrane). It focusses on different posttranslational modifications and gives examples of how these posttranslational modifications can alter protein folding and cause or accompany proteinopathies. Explore the complex relationship between posttranslational modifications and protein folding, and their impact on protein function and disease. Protein synthesis and its folding to form quaternary structures are generally not sufficient to produce a functional protein Proteins, soon after their translation, are often modified to achieve proper folding and localization. Many proteins undergo chemical modifications at certain amino acid residues following translation
These modifications are essential for normal functioning of the protein and are carried out by a one or more enzyme catalyzed reactions.
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