Two medications have been approved by the u.s Food and drug administration specifically for postpartum depression Brexanolone given intravenously, and zuranolone given orally. Antipsychotic medications may be needed as well as antidepressants A preexisting psychiatric disorder, including prior postpartum depression, is likely to recur or worsen during the puerperium, so affected women should be monitored closely. Abuse of some substances and illicit drugs (eg, alcohol, amphetamines) can lead to or accompany depression
Toxic effects or withdrawal of medications may cause transient depressive symptoms. Medications may be required for various indications during pregnancy The most commonly used medications include antiemetics, antacids, antihistamines, analgesics, antimicrobials, diuretics, antidepressants, and tranquilizers Substance use and misuse is also common Antiseizure medications that act as mood stabilizers, especially valproate and carbamazepine, are often used for acute mania and for mixed states (mania and depression) Obstetric and gynecologic history are often considered a distinct part of the medical history
Preeclampsia occurs in 4.6% and eclampsia in 1.4% of deliveries worldwide (1) Preeclampsia and eclampsia develop after 20 weeks gestation, although most cases occur after 34 weeks (2) Some cases develop postpartum, most often within the first 4 days but sometimes up to 6 weeks postpartum Untreated preeclampsia is present for a variable time, then can suddenly progress to eclampsia.
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