The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an rna component which serves as a template for the telomere repeat. Abnormal activation of telomerase occurs in most cancer types, which facilitates escaping from cell senescence As the key component of telomerase, telomerase reverse transcriptase (tert) is. In this review, we summarise the function and structure of telomerase reverse transcriptase (tert) in humans, including its regulation The dysregulation of telomerase through tert promoter mutations across a range of cancers is discussed The molecular mechanism activated by tert promoter mutations is outlined.
Telomerase reverse transcriptase (tert) is an enzyme that adds repetitive nucleotide sequences to the ends of chromosomes, known as telomeres, which helps to maintain chromosome stability during dna replication in eukaryotic cells. Telomerase maintains structures called telomeres, which are composed of repeated segments of dna found at the ends of chromosomes Telomeres protect chromosomes from abnormally sticking together or breaking down (degrading) In most cells, telomeres become progressively shorter as the cell divides. Telomerase reverse transcriptase (tert) is a subunit of the enzyme complex telomerase, which adds nucleotides to the ends of telomeres as they become shortened during cell division [95]. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an rna component that serves as a template for the telomere repeat.
Human telomeres consist of many kilobases of (ttaggg)n together with various associated proteins.
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